Fletcher Research Group
2018 - 2021
97) Selection between competing self-reproducing lipids: succession and dynamic activation
M. G. Howlett, R. J. Scanes and S. P. Fletcher
96) A catalytic asymmetric cross-coupling approach to the synthesis of cyclobutanes
F. W. Goetzke, A. M. L. Hell, L. van Dijk & S. P. Fletcher
Highlighted in 'Synfacts 2021, 17, 1016'
95) Acceleration of Lipid Reproduction by Emergence of Microscopic Motion
D. Babu, R. Scanes, R. Plamont, A. Ryabchun, F. Lancia, T. Kudernac, S. P. Fletcher, N. Katsonis
94) Additions to Racemates: A Strategy for Developing Asymmetric Cross-Coupling Reactions
F. W. Goetzke and S. P. Fletcher
93) Mechanistic investigation of Rh(I)-catalysed asymmetric Suzuki-Miyaura coupling with racemic allyl halides
L. van Dijk, R. Ardkhean, M. Sidera, S. Karabiyikoglu, Ö. Sari, T. D. W. Claridge, G. C. Lloyd-Jones, R. Paton, S. P. Fletcher
"Mechanism of the Month: in CellPress, Trends in Chemistry, Sept 2021, 9, 795-796."
92) A molecular assembler that produces polymers
A. H. J. Engwerda, S. P. Fletcher
Nature Communications Editors' Highlights
91) Emergence and rearrangement of dynamic supramolecular aggregates visualised by interferometric scattering microscopy
M. A. Lebedeva, E. Palmieri, P. Kukura, S. P. Fletcher
90) Dissipative self-assembly, competition and inhibition in a self-reproducing protocell model
E. A. J. Post and S. P. Fletcher
Highlighted in Chemistry World
89) Coupled metabolic cycles allow out‐of‐equilibrium autopoietic vesicle replication
A. H.J. Engwerda, J. Southworth, M. A. Lebedeva, R. J. H. Scanes, P. Kukura, S. P. Fletcher
88) Ligand Design for Asymmetric Catalysis: Combining Mechanistic and Chemoinformatics Approaches; Chapter 10 in New Directions in the Modeling of Organometallic Reactions. Springer 2020
R. Ardkhean, S. P. Fletcher, R. S. Paton
87) Synthesis of the Taxol Core via Catalytic Asymmetric 1,4-Addition of an Alkylzirconium Nucleophile
J. Y. J. Wang and S. P. Fletcher
86) Enantiomerically enriched tetrahydropyridine allyl chlorides
S. Karabiyikoglu, A. V. Brethomé, T. Palacin, R. S. Paton and S. P. Fletcher
85) An Asymmetric Suzuki–Miyaura Approach to Prostaglandins: Synthesis of Tafluprost
R. Kucera, F. W. Goetzke, S. P. Fletcher
'ACS Editors' Choice'
Highlighted in Synfacts 2020, 0750
84) Oligomerization driven by phase separation
I. Myrgorodska, I. Colomer, S. P. Fletcher
83) Selection from a pool of self-assembling lipid replicators
I. Colomer, A. Borissov, S. P. Fletcher
82) Catalytic Asymmetric Suzuki-Miyaura Coupling Reactions
F. W. Goetzke, L. van Dijk, S. P. Fletcher
81) Highly Enantioselective Rhodium-catalyzed Cross-coupling of Boronic Acids and Racemic Allyl Halides
J. González, L. van Dijk, F. W. Goetzke, S. P. Fletcher
80) Desymmetrization of Meso-bisphosphates via Rhodium Catalyzed Asymmetric Allylic Arylation
R. Jacques, A. M. L. Hell, R. D. C. Pullin, S. P. Fletcher
79) Retooling Asymmetric Conjugate Additions for Sterically Demanding Substrates with an Iterative Data-Driven Approach
A. V. Brethomé, R. S. Paton, S. P. Fletcher
78) Enantio‐ and diastereoselective Suzuki‐Miyaura coupling with racemic bicycles
F. W. Goetzke, M. Mortimore, S. P. Fletcher
‘Hot Paper'
77) Highly enantioselective Hiyama cross-coupling via Rh-catalyzed allylic arylation of racemic allyl chlorides
J. Gonzalez, P. Schafer, S. P. Fletcher
76) A chemically fuelled self-replicator
S. M. Morrow, I. Colomer, S. P. Fletcher
75) Conformational Effects on Physical-Organic Descriptors: The Case of Sterimol Steric Parameters
A. V. Brethomé, S. P. Fletcher, R. S. Paton
74) Controlling the Kinetics of Self-Reproducing Micelles by Catalyst Compartmentalization in a Biphasic System
E. A. J. Post, S. P. Fletcher
73) Desymmetrization of meso-bisphosphates using copper catalysis and alkylzirconocene nucleophiles
R. Jacques, R. Pullin, S. P. Fletcher
72) β-Chloroaldehydes from Trapping Zirconium Enolates Produced in Asymmetric 1, 4-Additions
J. Y. Wang, T. Palacin, S. P. Fletcher
71) Self-reproducing micelles coupled to a secondary catalyst
E. A. J. Post, A. Bissette, S. P. Fletcher
70) A transient self-assembling self-replicator
I. Colomer, S. M. Morrow, S. P. Fletcher
69) Catalytic Asymmetric Synthesis of Geminal-Dicarboxylates
N. Mistry, S. P. Fletcher
68) Construction of β to carbonyl stereogenic centres by asymmetric 1,4-addition of alkylzirconocenes to dienones and ynenones
Z. Gao, S. P. Fletcher
67) Molecular machines for catalysis
L. van Dijk, M. J. Tilby, R. Szpera, O. A. Smith, H. A. P. Bunce, S. P. Fletcher
66) Formation of quaternary centres by copper catalysed asymmetric conjugate addition to β-substituted cyclopentenones with the aid of a quantitative structure–selectivity relationship
R. Ardkhean, M. Mortimore, R. S. Paton, S. P. Fletcher